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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis

Fig. 2

MAC inhibitor completely blocks NLRP3 inflammasome components while, in contrast, C5aR1 inhibition only partially decreases expression. The inflammasome pathway was modeled by Ingenuity Pathway Analysis (IPA) after analyses of gene expression data from mouse spinal cords collected at relapse (3 mice/group). Genes showing higher expression levels in the first compared to the second group of each comparison are colored red. The grey color indicates no changes of expression levels. Note that genes linked to NLRP3 inflammasome activation show no changes of expression levels in the C6 antisense group (MAC inhibitor, genes colored grey), but increased levels in the PMX205 group (inhibitor of C5aR1-mediated inflammation, genes colored red) when compared with healthy controls at relapse (a-c). Log fold change values of genes are shown in Additional file 1: Table S4

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