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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Large inter- and intra-case variability of first generation tau PET ligand binding in neurodegenerative dementias

Fig. 6

T726 and THK-5117 fluorescent labelling of the FTDP-17 case with a R406W MAPT mutation. a) T726 and THK-75117 binding to the CA1 section of the hippocampus; fluorescent tracers in green, DAPI in blue, Nissl Neurotrace 640 in red; scale bar inset 100 μm. b) Frequencies of tau pathology depicted by the fluorescent tau ligands as compared to the amount of pathology immunodecorated by the phospho-tau specific antibody AT8. Frequencies: , extremely frequent; , very frequent, , frequent; , infrequent; , absent. Abbreviations: NFT, neurofibrillary tangles; PT, pre-tangles; NT, neuropil threads; FC, frontal cortex; TC, temporal cortex; HP, hippocampus; IHC, immunohistochemistry

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