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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Large inter- and intra-case variability of first generation tau PET ligand binding in neurodegenerative dementias

Fig. 2

Fluorescence imaging with T726 in Alzheimer’s disease cases and controls. a–o) T726 bound pathology in green, nuclear marker DAPI in blue; scale bar inset 50 μm. a–d) T726 bound mature tangle structures in individual Alzheimer’s disease cases. f–i) Pre-tangle inclusions bound by T726. k–n) Neuropil threads bound by T726. e/j/o) Representative images from the control case CTRL4 depict the absence of T726 binding in control cases. p–s) T726 labelling of an AT8 immunoreactive hippocampal neurofibrillary tangle (Alzheimer’s disease case AD1); T726 in green, AT8 in red, DAPI in blue; scale bar inset 25 μm. t) Representative image of T726 labelled structures negative for AT8, and AT8 immunodecorated tangles not labelled with T726 (Alzheimer’s disease case AD1); T726 in green, AT8 in red, DAPI in blue; scale bar inset; 50 μm. u) Representative immunofluorescence image showing distinct binding patterns of T726 and Aβ-XP to cortical pathology (Alzheimer’s disease case AD1); T726 in green, Aβ-XP in red, DAPI in blue; scale bar inset 50 μm. Abbreviations: AD, Alzheimer’s disease; CTRL, control; NFT, neurofibrillary tangles; PT, pre-tangles; NT, neuropil threads; FC, frontal cortex; TC, temporal cortex; HP, hippocampus; Aβ, amyloid-beta

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