Fig. 2From: Large inter- and intra-case variability of first generation tau PET ligand binding in neurodegenerative dementiasFluorescence imaging with T726 in Alzheimer’s disease cases and controls. a–o) T726 bound pathology in green, nuclear marker DAPI in blue; scale bar inset 50 μm. a–d) T726 bound mature tangle structures in individual Alzheimer’s disease cases. f–i) Pre-tangle inclusions bound by T726. k–n) Neuropil threads bound by T726. e/j/o) Representative images from the control case CTRL4 depict the absence of T726 binding in control cases. p–s) T726 labelling of an AT8 immunoreactive hippocampal neurofibrillary tangle (Alzheimer’s disease case AD1); T726 in green, AT8 in red, DAPI in blue; scale bar inset 25 μm. t) Representative image of T726 labelled structures negative for AT8, and AT8 immunodecorated tangles not labelled with T726 (Alzheimer’s disease case AD1); T726 in green, AT8 in red, DAPI in blue; scale bar inset; 50 μm. u) Representative immunofluorescence image showing distinct binding patterns of T726 and Aβ-XP to cortical pathology (Alzheimer’s disease case AD1); T726 in green, Aβ-XP in red, DAPI in blue; scale bar inset 50 μm. Abbreviations: AD, Alzheimer’s disease; CTRL, control; NFT, neurofibrillary tangles; PT, pre-tangles; NT, neuropil threads; FC, frontal cortex; TC, temporal cortex; HP, hippocampus; Aβ, amyloid-betaBack to article page