Skip to main content
Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Prion infectivity is encoded exclusively within the structure of proteinase K-resistant fragments of synthetically generated recombinant PrPSc

Fig. 1

Titer of recPrPSc infectivity determined by end-point titration with the Elispot cell infection assay (a) and the tga20 mouse bioassay (b). The same batch of recPrPSc was subjected to 10-fold serial dilution, and both undiluted and diluted recPrPSc were used to infect naïve CAD5 cells or to intracerebrally inoculate tga20 mice. In b, red dots indicate mice that reached the terminal stage of disease; green dots represent mice without any disease at the end of 365 dpi

Back to article page