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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods

Fig. 6

α-Syn strain-specific pathology in non-Tg mice. Inoculation of sarkosyl-insoluble fractions extracted from MSA brain (MSA-2, putamen, 5 μl) into WT mice induced PS129-positive inclusions in frontal cortex, striatum, amygdala and substantia nigra at 3 months after inoculation (middle). Sarkosyl-insoluble fractions extracted from DLB brain (5 μl) induced Lewy-neurite-like α-syn pathology at 9 months after inoculation (lower). Control brain did not induce α-syn pathology (upper). Sections were evaluated by immunohistochemistry with PSer129 antibody EP1536Y. The α-syn concentrations of sarkosyl-insoluble fractions derived from human brains are shown in Additional file 2: Table S1B. The numbers of injected mice are shown in Additional file 5: Table S2C. FC: frontal cortex, Str: striatum, Amy: amygdala, SN: substantia nigra

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