Fig. 11
From: Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods
Effects of inactivation treatments of pathogenic α-syn extracted from MSA patients’ brains on seeding activity in non-Tg mice, α-Syn pathology in mouse brains inoculated into striatum with sarkosyl-insoluble fractions extracted from MSA brain (MSA-2, putamen) after boiling or autoclaving (AC) at 134 °C, at 3 months after injection. The numbers of injected mice are shown in Additional file 5: Table S2C. Sections were evaluated by immunohistochemistry with PSer129 antibody EP1536Y. Scale bar, 100 μm. FC: frontal cortex, Str: striatum, Amy: amygdala, SN: substantia nigra