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Table 4 Relation of TDP-43 stages and age-related pathologies to cognitive outcomes

From: TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer’s disease

Model terms

Estimate (SE) p-value

Episodic Memory

Semantic Memory

Working Memory

Perceptual Speed

Visuospatial Abilities

TDP-43 stage 1a

0.05 (0.09) 0.591

0.06 (0.12) 0.592

0.08 (0.09) 0.374

0.10 (0.09) 0.273

0.12 (0.09) 0.174

TDP-43 stage 2a

−0.32 (0.12) 0.008

− 0.34 (0.15) 0.024

− 0.16 (0.11) 0.141

− 0..12 (0.12) 0.290

− 0.02 (0.11) 0.874

TDP-43 stage 3a

− 0.31 (0.14) 0.023

− 0.06 (0.17) 0.717

0.02 (0.13) 0.879

− 0.13 (0.13) 0.337

0.07 (0.13) 0.594

TDP-43 stage 4a

− 0.76 (0.15) < 0.001

− 0.34 (0.18) 0.064

−0.02 (0.13) 0.886

− 0.22 (0.14) 0.108

−0.08 (0.14) 0.574

TDP-43 stage 5a

−0.83 (0.18) < 0.001

− 0.97 (0.22) < 0.001

−0.24 (0.16) 0.142

− 0.61 (0.17) < 0.001

−0.20 (0.17) 0.254

AD pathology

−0.90 (0.06) < 0.001

− 0.96 (0.07) < 0.001

−0.55 (0.05) < 0.001

−0.54 (0.06) < 0.001

−0.40 (0.06) < 0.001

Macroinfarcts

−0.40 (0.08) < 0.001

−0.42 (0.10) < 0.001

−0.37 (0.07) < 0.001

−0.25 (0.07) < 0.001

−0.12 (0.07) 0.097

Microinfarcts

−0.08 (0.08) 0.288

−0.15 (0.10) 0.134

− 0.01 (0.07) 0.845

−0.14 (0.07) 0.053

− 0.01 (0.07) 0.905

Atherosclerosis

−0.14 (0.08) 0.078

− 0.10 (0.10) 0.321

−0.05 (0.07) 0.465

− 0.15 (0.07) 0.041

−0.14 (0.07) 0.063

Arteriolosclerosis

−0.23 (0.08) 0.003

−0.20 (0.10) 0.039

− 0.13 (0.07) 0.063

−0.19 (0.07) 0.011

− 0.12 (0.07) 0.107

Lewy body disease

−0.44 (0.08) < 0.001

− 0.79 (0.10) < 0.001

−0.42 (0.07) < 0.001

− 0.42 (0.08) < 0.001

−0.28 (0.08) < 0.001

Hippocampal sclerosis

−0.59 (0.14) < 0.001

− 0.66 (0.17) < 0.001

− 0.24 (0.12) 0.055

−0.21 (0.13) 0.100

− 0.34 (0.13) 0.009

  1. Cognitive outcomes are estimated from separate linear regressions, all adjusted for age at death, sex, and education. Cell entries are estimate, standard error (SE), and probability value
  2. arepresent contrasts with TDP-43 stage 0