From: TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer’s disease
Model terms | Estimate (SE) p-value | ||||
---|---|---|---|---|---|
Episodic Memory | Semantic Memory | Working Memory | Perceptual Speed | Visuospatial Abilities | |
TDP-43 stage 1a | 0.05 (0.09) 0.591 | 0.06 (0.12) 0.592 | 0.08 (0.09) 0.374 | 0.10 (0.09) 0.273 | 0.12 (0.09) 0.174 |
TDP-43 stage 2a | −0.32 (0.12) 0.008 | − 0.34 (0.15) 0.024 | − 0.16 (0.11) 0.141 | − 0..12 (0.12) 0.290 | − 0.02 (0.11) 0.874 |
TDP-43 stage 3a | − 0.31 (0.14) 0.023 | − 0.06 (0.17) 0.717 | 0.02 (0.13) 0.879 | − 0.13 (0.13) 0.337 | 0.07 (0.13) 0.594 |
TDP-43 stage 4a | − 0.76 (0.15) < 0.001 | − 0.34 (0.18) 0.064 | −0.02 (0.13) 0.886 | − 0.22 (0.14) 0.108 | −0.08 (0.14) 0.574 |
TDP-43 stage 5a | −0.83 (0.18) < 0.001 | − 0.97 (0.22) < 0.001 | −0.24 (0.16) 0.142 | − 0.61 (0.17) < 0.001 | −0.20 (0.17) 0.254 |
AD pathology | −0.90 (0.06) < 0.001 | − 0.96 (0.07) < 0.001 | −0.55 (0.05) < 0.001 | −0.54 (0.06) < 0.001 | −0.40 (0.06) < 0.001 |
Macroinfarcts | −0.40 (0.08) < 0.001 | −0.42 (0.10) < 0.001 | −0.37 (0.07) < 0.001 | −0.25 (0.07) < 0.001 | −0.12 (0.07) 0.097 |
Microinfarcts | −0.08 (0.08) 0.288 | −0.15 (0.10) 0.134 | − 0.01 (0.07) 0.845 | −0.14 (0.07) 0.053 | − 0.01 (0.07) 0.905 |
Atherosclerosis | −0.14 (0.08) 0.078 | − 0.10 (0.10) 0.321 | −0.05 (0.07) 0.465 | − 0.15 (0.07) 0.041 | −0.14 (0.07) 0.063 |
Arteriolosclerosis | −0.23 (0.08) 0.003 | −0.20 (0.10) 0.039 | − 0.13 (0.07) 0.063 | −0.19 (0.07) 0.011 | − 0.12 (0.07) 0.107 |
Lewy body disease | −0.44 (0.08) < 0.001 | − 0.79 (0.10) < 0.001 | −0.42 (0.07) < 0.001 | − 0.42 (0.08) < 0.001 | −0.28 (0.08) < 0.001 |
Hippocampal sclerosis | −0.59 (0.14) < 0.001 | − 0.66 (0.17) < 0.001 | − 0.24 (0.12) 0.055 | −0.21 (0.13) 0.100 | − 0.34 (0.13) 0.009 |