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Table 4 Relation of TDP-43 stages and age-related pathologies to cognitive outcomes

From: TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer’s disease

Model terms Estimate (SE) p-value
Episodic Memory Semantic Memory Working Memory Perceptual Speed Visuospatial Abilities
TDP-43 stage 1a 0.05 (0.09) 0.591 0.06 (0.12) 0.592 0.08 (0.09) 0.374 0.10 (0.09) 0.273 0.12 (0.09) 0.174
TDP-43 stage 2a −0.32 (0.12) 0.008 − 0.34 (0.15) 0.024 − 0.16 (0.11) 0.141 − 0..12 (0.12) 0.290 − 0.02 (0.11) 0.874
TDP-43 stage 3a − 0.31 (0.14) 0.023 − 0.06 (0.17) 0.717 0.02 (0.13) 0.879 − 0.13 (0.13) 0.337 0.07 (0.13) 0.594
TDP-43 stage 4a − 0.76 (0.15) < 0.001 − 0.34 (0.18) 0.064 −0.02 (0.13) 0.886 − 0.22 (0.14) 0.108 −0.08 (0.14) 0.574
TDP-43 stage 5a −0.83 (0.18) < 0.001 − 0.97 (0.22) < 0.001 −0.24 (0.16) 0.142 − 0.61 (0.17) < 0.001 −0.20 (0.17) 0.254
AD pathology −0.90 (0.06) < 0.001 − 0.96 (0.07) < 0.001 −0.55 (0.05) < 0.001 −0.54 (0.06) < 0.001 −0.40 (0.06) < 0.001
Macroinfarcts −0.40 (0.08) < 0.001 −0.42 (0.10) < 0.001 −0.37 (0.07) < 0.001 −0.25 (0.07) < 0.001 −0.12 (0.07) 0.097
Microinfarcts −0.08 (0.08) 0.288 −0.15 (0.10) 0.134 − 0.01 (0.07) 0.845 −0.14 (0.07) 0.053 − 0.01 (0.07) 0.905
Atherosclerosis −0.14 (0.08) 0.078 − 0.10 (0.10) 0.321 −0.05 (0.07) 0.465 − 0.15 (0.07) 0.041 −0.14 (0.07) 0.063
Arteriolosclerosis −0.23 (0.08) 0.003 −0.20 (0.10) 0.039 − 0.13 (0.07) 0.063 −0.19 (0.07) 0.011 − 0.12 (0.07) 0.107
Lewy body disease −0.44 (0.08) < 0.001 − 0.79 (0.10) < 0.001 −0.42 (0.07) < 0.001 − 0.42 (0.08) < 0.001 −0.28 (0.08) < 0.001
Hippocampal sclerosis −0.59 (0.14) < 0.001 − 0.66 (0.17) < 0.001 − 0.24 (0.12) 0.055 −0.21 (0.13) 0.100 − 0.34 (0.13) 0.009
  1. Cognitive outcomes are estimated from separate linear regressions, all adjusted for age at death, sex, and education. Cell entries are estimate, standard error (SE), and probability value
  2. arepresent contrasts with TDP-43 stage 0
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