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Table 3 Relation of the five TDP-43 positive stages and age-related pathologies to dementia

From: TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer’s disease

Model terms Relation to dementia
OR (95% CI) p-value
TDP-43 stage 1a 0.91 (0.62,1.35) 0.645
TDP-43 stage 2a 1.38 (0.84, 2.24) 0.203
TDP-43 stage 3a 2.68 (1.51, 4.75) < 0.001
TDP-43 stage 4a 1.90 (1.05, 3.42) 0.034
TDP-43 stage 5a 5.20 (2.23, 12.1) < 0.001
AD Pathology 3.81 (2.93, 4.96) < 0.001
Macroinfarcts 2.27 (1.66, 3.11) < 0.001
Microinfarcts 1.26 (0.91,1.74) 0.167
Atherosclerosis 1.48 (1.07, 2.04) 0.019
Arteriolosclerosis 1.38 (1.00,1.90) 0.054
Lewy bodies 3.09 (2.20, 4.34) < 0.001
Hippocampal sclerosis 3.48 (1.86, 6.49) < 0.001
  1. Estimated from multiple logistic regression models, adjusted for age at death, sex and education
  2. arepresents contrasts with TDP-43 stage 0
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