From: TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer’s disease
Model terms | Relation to dementia | |
---|---|---|
OR (95% CI) | p-value | |
TDP-43 stage 1a | 0.91 (0.62,1.35) | 0.645 |
TDP-43 stage 2a | 1.38 (0.84, 2.24) | 0.203 |
TDP-43 stage 3a | 2.68 (1.51, 4.75) | < 0.001 |
TDP-43 stage 4a | 1.90 (1.05, 3.42) | 0.034 |
TDP-43 stage 5a | 5.20 (2.23, 12.1) | < 0.001 |
AD Pathology | 3.81 (2.93, 4.96) | < 0.001 |
Macroinfarcts | 2.27 (1.66, 3.11) | < 0.001 |
Microinfarcts | 1.26 (0.91,1.74) | 0.167 |
Atherosclerosis | 1.48 (1.07, 2.04) | 0.019 |
Arteriolosclerosis | 1.38 (1.00,1.90) | 0.054 |
Lewy bodies | 3.09 (2.20, 4.34) | < 0.001 |
Hippocampal sclerosis | 3.48 (1.86, 6.49) | < 0.001 |