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Table 3 Relation of the five TDP-43 positive stages and age-related pathologies to dementia

From: TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer’s disease

Model terms

Relation to dementia

OR (95% CI)

p-value

TDP-43 stage 1a

0.91 (0.62,1.35)

0.645

TDP-43 stage 2a

1.38 (0.84, 2.24)

0.203

TDP-43 stage 3a

2.68 (1.51, 4.75)

< 0.001

TDP-43 stage 4a

1.90 (1.05, 3.42)

0.034

TDP-43 stage 5a

5.20 (2.23, 12.1)

< 0.001

AD Pathology

3.81 (2.93, 4.96)

< 0.001

Macroinfarcts

2.27 (1.66, 3.11)

< 0.001

Microinfarcts

1.26 (0.91,1.74)

0.167

Atherosclerosis

1.48 (1.07, 2.04)

0.019

Arteriolosclerosis

1.38 (1.00,1.90)

0.054

Lewy bodies

3.09 (2.20, 4.34)

< 0.001

Hippocampal sclerosis

3.48 (1.86, 6.49)

< 0.001

  1. Estimated from multiple logistic regression models, adjusted for age at death, sex and education
  2. arepresents contrasts with TDP-43 stage 0