Skip to main content

Table 2 Clinical pathologic characteristics of 1108 participants by TDP-43 stages

From: TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer’s disease

Characteristics TDP-43 Stages p-value
Stage 0 n = 561 Stage 1 n = 206 Stage 2 n = 112 Stage 3 n = 85 Stage 4 n = 83 Stage 5 n = 61
Age at death, y, mean (SD) 87.7 (6.9) 89.6 (6.6) 91.5 (6.1) 92.0 (5.6) 92.1 (5.3) 90.3 (5.3) < 0.001*
Female, n (%) 370 (66.0) 144 (69.9) 79 (70.5) 67 (78.8) 67 (80.7) 41 (67.2) 0.036
Education, mean (SD), 16.1 (3.9) 16.2 (3.6) 16.1 (3.6) 15.7 (3.5) 15.5 (3.4) 15.8 (3.3) 0.705*
Clinical characteristics, n (%)
No Dementia 376 (67.4) 130 (63.1) 55 (49.1) 30 (35.3) 27 (32.9) 9 (14.8) < 0.001
Dementia 182 (32.6) 76 (36.9) 57 (50.9) 55 (64.7) 55 (67.1) 52 (85.3)
Cognitive function tests proximate to death, mean (SD)
MMSE score 22.8 (8.2) 21.5 (8.6) 19.0 (9.8) 18.3 (9.5) 15.6 (9.2) 11.2 (10.5) < 0.001*
Episodic memory −0.60 (1.3) −0.71 (1.3) −1.23 (1.4) −1.38 (1.3) −1.97 (1.2) −2.19 (1.3) < 0.001*
Semantic memory −0.91 (1.5) −1.05 (1.5) −1.63 (1.9) −1.51 (1.7) −1.96 (1.7) −2.80 (2.1) < 0.001*
Working memory −0.61 (1.1) −0.65 (1.1) − 0.95 (1.2) −0.87 (1.0) − 0.97 (1.0) − 1.27 (1.3) < 0.001*
Perceptual speed − 1.03 (1.2) − 1.08 (1.1) − 1.42 (1.2) −1.51 (1.1) − 1.68 (1.1) −2.10 (1.2) < 0.001*
Visuospatial ability − 0.42 (1.1) −0.41 (1.2) − 0.64 (1.2) −0.68 (1.1) − 0.91 (1.1) − 1.05 (1.3) < 0.001*
Pathologic characteristics, n (%)
AD, NIA-Reagan 315 (56.2) 136 (66.0) 75 (67.0) 68 (80.0) 71 (85.5) 52 (85.3) < 0.001
Hippocampal sclerosis 10 (1.8) 7 (3.4) 14 (12.5) 14 (16.5) 27 (32.5) 38 (62.3) < 0.001
Macroinfarcts 196 (34.9) 77 (37.4) 38 (33.9) 29 (34.1) 37 (44.6) 21 (34.4) 0.724
Microinfarcts 158 (28.2) 61 (29.6) 36 (32.1) 21 (24.8) 26 (31.3) 23 (37.7) 0.678
Arteriolosclerosis 161 (28.9) 76 (37.1) 32 (28.6) 33 (38.8) 30 (36.1) 20 (29.5) 0.145
Atherosclerosis 174 (31.1) 71 (34.5) 37 (33.0) 27 (31.8) 28 (33.7) 20 (32.8) 0.966
Cerebral amyloid angiopathy 418 (75.2) 155 (75.6) 95 (84.8) 69 (81.2) 66 (79.5) 51 (83.6) 0.171
Lewy body disease 115 (21.1) 50 (24.9) 32 (29.4) 24 (29.6) 16 (20.5) 25 (40.0) 0.008
  1. p-value derived from ANOVA* or chi-square
\