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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism

Fig. 2

AZT inhibits P2RX7 large pore and channel functions in mdx myoblasts a EtBr uptake (expressed as % permeabilization evoked by 50 μg/ml digitonin) following 30 min exposure to 1 mM BzATP with and without the specified concentrations of AZT. Note the concentration-dependent inhibition up to 20 μM of AZT. One-way ANOVA, df = 5, n = 6, p = 0.008. b 1 mM BzATP-stimulated Ca2+ influx was inhibited in the presence of 20 μM AZT or me-AZT. One-way ANOVA, df = 3, n = 4, p = 0.001. Error bars show mean ± SD, **p < 0 .01

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