Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression

Table 1 Summary of Aβ pathology in inoculated App^NL-F mice

Inoculum	Days post-inoculation	Age (d)	Sex	Aβ deposition^a (n/n₀^b)
Inoculum	Days post-inoculation	Age (d)	Sex	Subcallosal region	Hippocampus	Cortex	Olfactory bulb	Meningeal CAA
Purified TgCRND8 Aβ	14	56	Male	0/5	0/5	0/5	0/5	0/5
Purified TgCRND8 Aβ	130	172	Male	4/4	0/4	0/4	4/4	4/4
BSA	132	174	Male	0/5	0/4	0/5	0/5	1/5
	151	193	Male	0/5	0/5	1/5	0/5	0/5
			Female	0/4	0/4	1/4	0/4	0/4
TgCRND8–1	30	74	Female	0/2	0/2	0/2	0/2	0/2
	60	104	Female	2/2	0/2	0/2	0/2	1/2
	90	134	Female	2/2	0/2	0/2	1/2	2/2
	150	194	Male	3/3	0/3	1/3	2/3	3/3
			Female	2/2	0/2	0/2	1/2	2/2
TgCRND8–2	152	195	Male	3/4	0/4	0/4	2/4	4/4
TgCRND8–2			Female	4/4	0/4	2/4	2/4	4/4
AD-1	150	197	Male	3/4	0/4	0/4	3/4	4/4
AD-1			Female	3/4	0/4	1/4	1/4	4/4
AD-2	151	195	Male	3/3	0/3	0/3	1/3	3/3
AD-2			Female	4/5	0/5	2/5	3/5	5/5

^aAβ deposition was assessed by immunohistochemistry using the anti-Aβ antibody 4G8
^bn, number of positive mice; n₀, number of analyzed mice; a sample was scored as positive if there was clear evidence for Aβ deposition or at least one Aβ CAA-positive meningeal blood vessel

ISSN: 2051-5960