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Table 1 Summary of Aβ pathology in inoculated AppNL-F mice

From: Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression

Inoculum Days post-inoculation Age (d) Sex Aβ depositiona (n/n0b)
Subcallosal region Hippocampus Cortex Olfactory bulb Meningeal CAA
Purified TgCRND8 Aβ 14 56 Male 0/5 0/5 0/5 0/5 0/5
130 172 Male 4/4 0/4 0/4 4/4 4/4
BSA 132 174 Male 0/5 0/4 0/5 0/5 1/5
151 193 Male 0/5 0/5 1/5 0/5 0/5
   Female 0/4 0/4 1/4 0/4 0/4
TgCRND8–1 30 74 Female 0/2 0/2 0/2 0/2 0/2
60 104 Female 2/2 0/2 0/2 0/2 1/2
90 134 Female 2/2 0/2 0/2 1/2 2/2
150 194 Male 3/3 0/3 1/3 2/3 3/3
   Female 2/2 0/2 0/2 1/2 2/2
TgCRND8–2 152 195 Male 3/4 0/4 0/4 2/4 4/4
   Female 4/4 0/4 2/4 2/4 4/4
AD-1 150 197 Male 3/4 0/4 0/4 3/4 4/4
   Female 3/4 0/4 1/4 1/4 4/4
AD-2 151 195 Male 3/3 0/3 0/3 1/3 3/3
   Female 4/5 0/5 2/5 3/5 5/5
  1. aAβ deposition was assessed by immunohistochemistry using the anti-Aβ antibody 4G8
  2. bn, number of positive mice; n0, number of analyzed mice; a sample was scored as positive if there was clear evidence for Aβ deposition or at least one Aβ CAA-positive meningeal blood vessel