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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression

Fig. 6

Aβ cerebral amyloid angiopathy in AppNL-F mice inoculated with purified TgCRND8 Aβ aggregates. a Brain sections from male AppNL-F mice at 130–132 dpi with either BSA or purified TgCRND8 Aβ aggregates were analyzed by immunohistochemistry for Aβ40 (11A50-B10 antibody), Aβ42 (12F4 antibody), or Aβ43 (9C4 antibody), or by staining with Thio S. Representative images of the meningeal blood vessels are shown. Scale bar: 10 μm (applies to all images). b Quantification of Aβ CAA (percentage of 4G8-positive vessels; mean ± s.d.) in the meningeal blood vessels of uninoculated AppNL-F mice at 6 months of age (n = 4) as well as AppNL-F mice at 130–132 dpi with either BSA (n = 5) or purified TgCRND8 Aβ aggregates (n = 4). ***P < 0.001. c Quantification of CAA Aβ isoform composition (percentage of Aβ40-, Aβ42-, or Aβ43-positive vessels; mean ± s.d.) in the meningeal blood vessels of AppNL-F mice at 130 dpi with purified TgCRND8 Aβ aggregates (n = 4). **P < 0.01, *P < 0.05

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