Fig. 1
From: Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression
Induction of cerebral Aβ deposition in AppNL-F mice inoculated with partially purified Aβ aggregates. a The brains of male mice inoculated with BSA or partially purified Aβ aggregates from the brains of aged TgCRND8 mice or sporadic AD patients were analyzed by Aβ immunohistochemistry (4G8 antibody) at 150–152 dpi. Representative sections from the corpus callosum, olfactory bulb, and meningeal blood vessels of inoculated mice are shown. Scale bars: 20 μm. b Total (formic acid-extractable) Aβ42 levels (mean ± s.d.), as determined by ELISA, in brain homogenates from AppNL-F mice at 150–152 dpi with partially purified TgCRND8 Aβ aggregates (two samples, n = 5 and 8) or partially purified AD Aβ aggregates (two samples, n = 8 each) are significantly higher than in mice injected with BSA (n = 8). ***P < 0.001; **P < 0.01; *P < 0.05