Fig. 5

Non-ALS, non-IBM samples were negative for pTDP-43 pathology. Representative brain section control from a patient with frontotemporal lobar degeneration (top left panel), stained for pTDP-43, followed by H&E-stained section and positive pTDP-43 myofiber in an ALS patient. Bottom panels show pTDP-43 negative results in a patient with long-term steroid use and profound fiber atrophy and two samples of pTDP-43-negative paraspinous muscle obtained in the course of laminectomy in non-ALS patients. Images in the top row all photographed at 400×, except for the inset of pTDP-43 staining at the top right (600×) for sample ALS43. Images in the bottom row all photographed at 200×