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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis

Fig. 1

p62 Ick and pTDP-43 immunohistochemistry demonstrate p62-immunoreactive and pTDP-43-immunoreactive inclusions in three different IBM samples (left panels) and three different ALS samples (right panels; these examples all from paraspinous muscle). Immunofluorescence studies (bottom row) demonstrate co-localization of p62 Ick and pTDP-43 in both IBM and ALS samples, although p62 is the more sensitive of the two in detecting subsarcolemmal/ sarcolemmal inclusion pathology. Top two rows (immunohistochemistry) photographed at 400× and bottom row (immunofluorescence) photographed at 600×

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