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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Clinical significance of polyglutamylation in primary central nervous system lymphoma

Fig. 1

The PCNSL protocol used at our institute. A course of HD-MTX-based chemotherapy with LV rescue was administered every 3 weeks, with three such courses performed. Patients with PCNSL aged < 60 years were supposed to undergo RT from 4 weeks after the completion of three courses of HD-MTX treatment. Patients aged ≥60 years were monitored for CR to the therapy during follow-up evaluation after completion of the three courses. Alternatively, they underwent RT or other chemotherapies, such as temozolomide (TMZ), ICE (ifosphamide, cisplatin, and etoposide), or PE (carboplatin and etoposide). If PD occurred before the three courses of HD-MTX were completed, patients aged < 60 years underwent RT, whereas patients aged ≥60 years underwent RT or other chemotherapies. Second-line treatments were not uniform in cases of recurrence after HD-MTX therapies with or without RT. Patients who showed recurrence underwent TMZ, ICE, and PE treatment

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