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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival

Fig. 3

CD74 promoter methylation and whole DNA methylation patterns in NSCLC BM. a Mean beta-values of promoter-associated CpGs in 21 BM from NSCLC. CD74 low expressors are associated with significantly increased mean beta-values. b Differentially methylated CpGs of 21 BM from NSCLC, stratified by the combinatory parameters CD74 high + TILs high (CD74 TILs high, n = 5, blue) versus tumors not showing these combined features (CD74 TILs low, n = 16, yellow). Hierarchical cluster analysis showing 74 differentially methylated CpGs (M-values are shown, unadjusted p-value < 0.0001, Additional file 4: Table S1). c Gene ontology enrichment analysis of biological processes, (d) gene ontology enrichment analysis of Immune System processes

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Acta Neuropathologica Communications

ISSN: 2051-5960

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