Fig. 1

CD74 expression in human brain metastases. a Immunohistochemical staining against CD74 in three examples of BM from NSCLC, breast carcinoma and melanoma. b Example for CD74 and panCK showing co-expression in a NSCLC BM. c H-Score mean values and standard error of the mean (SEM) of all investigated BM entities (mean CD74 H-Score values: carcinoma NOS 79.4 (n = 8); colon carcinoma 51.4 (n = 10); breast carcinoma 42.5 (n = 31); RCC 133.9 (n = 18); NSCLC 73.2 (n = 56); SCLC 16.3 (n = 8); melanoma 26.5 (n = 96); others 71.1 (n = 9)). d Kaplan-Meier Survival analyses in the total BM cohort and in the subcohorts of NSCLC and melanoma after median split (median H-Score 20) according to CD74 expression