TY - JOUR AU - Zeiner, P. S. AU - Zinke, J. AU - Kowalewski, D. J. AU - Bernatz, S. AU - Tichy, J. AU - Ronellenfitsch, M. W. AU - Thorsen, F. AU - Berger, A. AU - Forster, M. T. AU - Muller, A. AU - Steinbach, J. P. AU - Beschorner, R. AU - Wischhusen, J. AU - Kvasnicka, H. M. AU - Plate, K. H. AU - Stefanović, S. AU - Weide, B. AU - Mittelbronn, M. AU - Harter, P. N. PY - 2018 DA - 2018/03/01 TI - CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival JO - Acta Neuropathologica Communications SP - 18 VL - 6 IS - 1 AB - Despite multidisciplinary local and systemic therapeutic approaches, the prognosis for most patients with brain metastases is still dismal. The role of adaptive and innate anti-tumor response including the Human Leukocyte Antigen (HLA) machinery of antigen presentation is still unclear. We present data on the HLA class II-chaperone molecule CD74 in brain metastases and its impact on the HLA peptidome complexity. SN - 2051-5960 UR - https://doi.org/10.1186/s40478-018-0521-5 DO - 10.1186/s40478-018-0521-5 ID - Zeiner2018 ER -