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Table 5 LINCS database analysis identified compounds that up-regulate or down-regulate the gene expression of Cebpd, Pax6, Spi1 and Tp73 transcription factors. Identification of compounds regulating the expression of transcription factors were carried out by retrieving compound-induced transcription profiles in terminally differentiated neurons, terminally differentiated neurons treated with KCl, and iPS-derived neural progenitor cells

From: Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

TF Upregulating compounds Downregulating compounds
Cebpd aminobenztropine (NEU), BG-1002 (NEU.KCL), BG-1011 (NPC), BIIB021 (NPC), BRD-A06779035 (NPC), BRD-A70591769 (NEU), BRD-A75769921 (NEU.KCL), BRD-A92334183 (NEU), BRD-K01608965 (NPC), BRD-K07381195 (NPC), BRD-K12683703 (NPC), BRD-K15050703 (NPC), BRD-K15935695 (NPC), BRD-K16934333 (NPC), BRD-K20126873 (NPC), BRD-K21374126 (NPC), BRD-K23986500 (NPC), BRD-K24798550 (NPC), BRD-K25164076 (NPC), BRD-K25990552 (NEU), BRD-K28934562 (NPC), BRD-K30229575 (NPC), BRD-K32885145 (NPC), BRD-K36269259 (NEU), BRD-K36313546 (NPC), BRD-K36591038 (NPC), BRD-K36796217 (NPC), BRD-K39597586 (NPC), BRD-K40300908 (NPC), BRD-K41871066 (NPC), BRD-K43631199 (NPC), BRD-K44540157 (NPC), BRD-K49111930 (NPC), BRD-K54331210 (NPC), BRD-K55536701 (NPC), BRD-K57166447 (NPC), BRD-K58808184 (NPC), BRD-K59253994 (NPC), BRD-K62970326 (NPC), BRD-K63494246 (NEU), BRD-K64523453 (NPC), BRD-K65148580 (NPC), BRD-K65657366 (NPC), BRD-K72354054 (NPC), BRD-K73008154 (NPC), BRD-K77888550 (NPC), BRD-K78133682 (NPC), BRD-K79947405 (NPC), BRD-K80062189 (NPC), BRD-K80138901 (NPC), BRD-K80400482 (NEU), BRD-K85133207 (NPC), BRD-K86110682 (NPC), BRD-K91844626 (NEU), BRD-K93158953 (NPC), BRD-K99718824 (NPC), cabergoline (NEU), chlorpromazine (NEU), deoxycholic-acid (NEU), econazole (NPC), farnesylthioacetic-acid (NPC), fluspirilene (NEU), geldanamycin (NPC), GSK-461364 (NPC), GW-3965 (NPC), GW-441756 (NPC), IQ1 (NEU), IQ1 (NPC), isoflupredone (NPC), ITSA-1 (NPC), IWP-2 (NEU), LY-255283 (NPC), LY-294002 (NPC), menadione (NPC), NVP-BEZ235 (NPC), PD-173074 (NPC), PI-828 (NPC), quercetin (NPC), R-96544 (NPC), scoulerine (NPC), serotonin (NPC), spermidine (NEU), SR-142948 (NEU), ST-023431 (NPC), ST-056792 (NPC), suberoyl-bis-hydroxamic-acid (NEU), tamoxifen (NPC), tozasertib (NPC), tranylcypromine (NEU.KCL), triacetylresveratrol (NPC), trichostatin-a (NEU), trifluridine (NPC), vorinostat (NPC) BRD-K89824424 (NPC), O-1918 (NPC)
Pax6 acetyl-farnesyl-cysteine (NEU.KCL), BRD-K02409808 (NEU), BRD-K24656059 (NPC), BRD-K45842176 (NPC), clofibric-acid (NPC), rolipram (NPC), SKF-96365 (NPC), thioproperazine (NPC) apicidin (NEU.KCL), BG-1016 (NPC), BRD-K37650321 (NEU), chrysamine-g (NEU), proadifen (NPC), XMD-1150 (NEU)
Spi1 BRD-K39172790 (NEU), timosaponin (NEU) AS-703026 (NPC), genistein (NPC), U-0126 (NPC)
Tp73 BRD-K16827616 (NPC), BRD-K78133682 (NPC), RG-14620 (NPC), trimipramine (NEU), wortmannin (NEU)
  1. Abbreviations: NEU terminally differentiated neurons, NEU.KCL terminally differentiated neurons treated with, NPC iPS-derived neural progenitor cells, TF transcription factor