Skip to main content

Table 1 Gene promoter methylation and gene expression of Wdr26, Lrp1b, Ppid and Gpr12 in perilesional cortex, hippocampus and ipsilateral thalamus according MBD and RNA-seq

From: Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

   Wdr26 Lrp1b Ppid Gpr12
Perilesional Cx Gene expression
log2FC − 0.161 − 0.441 − 0.222 − 0.531
FDR 0.300607 0.022273 0.242403 0.000197
Methylation
log2FC 0.313 1.402 0.038 1.407
FDR 1 0.01901 1 0.014662
Hippocampus Gene expression
log2FC −0.129 −0.166 −0.036 0.224
FDR 0.999825 0.999825 0.999825 0.999825
Methylation
log2FC 2.660 −0.602 1.930 0.179
FDR 1.87E-14 1 1.4E-07 1
Thalamus Gene expression
log2FC 0.140 −0.097 −0.074 − 0.687
FDR 0.721246 0.795279 0.873954 0.000388
Methylation
log2FC 0.241 0.159 0.059 −0.014
FDR 1 1 1 1
  1. Abbreviations: Cx perilesional cortex, FC fold-change. Statistical significances: log2FC change and corresponding FDR (< 0.05) are shown in bolded font