Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

Table 1 Gene promoter methylation and gene expression of Wdr26, Lrp1b, Ppid and Gpr12 in perilesional cortex, hippocampus and ipsilateral thalamus according MBD and RNA-seq

		Wdr26	Lrp1b	Ppid	Gpr12
Perilesional Cx	*Gene expression*
	log2FC	− 0.161	− 0.441	− 0.222	− 0.531
	FDR	0.300607	0.022273	0.242403	0.000197
	*Methylation*
	log2FC	0.313	1.402	0.038	1.407
	FDR	1	0.01901	1	0.014662
Hippocampus	*Gene expression*
	log2FC	−0.129	−0.166	−0.036	0.224
	FDR	0.999825	0.999825	0.999825	0.999825
	*Methylation*
	log2FC	2.660	−0.602	1.930	0.179
	FDR	1.87E-14	1	1.4E-07	1
Thalamus	*Gene expression*
	log2FC	0.140	−0.097	−0.074	− 0.687
	FDR	0.721246	0.795279	0.873954	0.000388
	*Methylation*
	log2FC	0.241	0.159	0.059	−0.014
	FDR	1	1	1	1

Abbreviations: Cx perilesional cortex, FC fold-change. Statistical significances: log2FC change and corresponding FDR (< 0.05) are shown in bolded font

ISSN: 2051-5960