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Table 2 Characterization and location of PrPSc deposits in tg66 mice injected with Y226X human brain tissue

From: Familial human prion diseases associated with prion protein mutations Y226X and G131V are transmissible to transgenic mice expressing human prion protein

 

Brain regionsa

Dpib

Pons

Thalamus

Superior Colliculus

Hypothalamus

Cerebral cortex

593

P

C

C

P

neg

601

P&PN

C

C

PN

PN

716

P&PN

neg

neg

P

P (rare)

718

P&PN

neg

C (rare)

neg

C (weak)

  1. a-Types of PrPSc deposits seen in the indicated brain regions: P = plaque-like, PN = perineuronal linear or pericellular deposits, C = coarse deposits in neuropil, neg = negative
  2. b-Days post-injection with human Y226X brain tissue
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Acta Neuropathologica Communications

ISSN: 2051-5960

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