Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC

Table 1 Demographic data and cognitive impairment at the time of lumbar puncture (LP) in studied subjects

Final diagnosis	n	Age at onset (years)	Age at LP (years)	Mean interval between onset and LP (years)	Sex (M:F)	MMSE^a
Dementia with Lewy Bodies	17	69.6 ± 7.8	73.8 ± 7.8	4.2	17:2	23.0 ± 4.6
Parkinson’s Disease	12	63.1 ± 12.0	66.0 ± 12.9	2.9	11:1	28.9 ± 1.1
Alzheimer’s Disease	16	69.9 ± 9.1	73.9 ± 9.1	4	12:4	22.9 ± 3.3
Control^b	12	n/a	71.3 ± 7.0	n/a	4:8	28.8 ± 1.2
Other^b	3	65.7 ± 11.4	67.7 ± 10.7	2	2:1	20.5 ± 8.1

^aMMSE: Mini–Mental State Examination, ^b“controls” and “others” were grouped into “non-synucleinopathies” for analysis

ISSN: 2051-5960