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Table 1 Demographic data and cognitive impairment at the time of lumbar puncture (LP) in studied subjects

From: Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC

Final diagnosis n Age at onset (years) Age at LP (years) Mean interval between onset and LP (years) Sex (M:F) MMSEa
Dementia with Lewy Bodies 17 69.6 ± 7.8 73.8 ± 7.8 4.2 17:2 23.0 ± 4.6
Parkinson’s Disease 12 63.1 ± 12.0 66.0 ± 12.9 2.9 11:1 28.9 ± 1.1
Alzheimer’s Disease 16 69.9 ± 9.1 73.9 ± 9.1 4 12:4 22.9 ± 3.3
Controlb 12 n/a 71.3 ± 7.0 n/a 4:8 28.8 ± 1.2
Otherb 3 65.7 ± 11.4 67.7 ± 10.7 2 2:1 20.5 ± 8.1
  1. aMMSE: Mini–Mental State Examination, b“controls” and “others” were grouped into “non-synucleinopathies” for analysis