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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Exceptional in vivo catabolism of neurodegeneration-related aggregates

Fig. 5

The general capability of bdelloid rotifers to catabolise neurotoxic aggregates. Neurodegeneration-related peptide and protein aggregates can be utilized as nutrients when given as the only potential energy source for starved bdelloid rotifer species. These agents proved to be either toxic or ineffective for monogonant and non-rotifer species. A currently unidentified mechanism in bdelloid rotifers is hypothesized to enable the utilization of amino acids derived from the degraded aggregates for gluconeogenesis. Compared to the unfed (starved) controls, the bdelloid rotifers treated with aggregates (‘fed’) demonstrate increased survival and viability

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