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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis

Fig. 3

During EAE, surfen reduces cellular infiltration into spinal cord and/or cerebellum. a CD4 positive T cells, b F4/80, CD11b positive macrophages. Upper panels show % changes in spinal cord and cerebellum for 4 groups. CFA + PTX controls treated with vehicle (CFA-V) or surfen (CFA-S) are compared to EAE treated with vehicle (EAE-V) or surfen (EAE-S). Lower panels illustrate the gating strategy used to calculate the data. Grouped data is shown as mean ± SEM; significant data is marked, comparing vehicle treated EAE with CFA-vehicle control (# = P < 0.05) or between groups as indicated by cross bars (* = P < 0.05)

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