Fig. 3

Location of IsoD-Aβ and pE3-Aβ immunostaining. Illustrations of the different neuropathological features detected by immunostaining for IsoD-Aβ (upper panel) and pE3-Aβ (lower panel): intraneuronal (a, f*), diffuse deposits (b, g), core plaques (c, h), and cerebral amyloid angiopathy (CAA) (d, i). The assessment of the different neuropathological features shows that: (e) IsoD-Aβ in CAA, core plaques and neurons was significantly more frequent in AD vs OC; however intraneuronal IsoD-Aβ was limited to only 18% of AD cases; (j) pE3-Aβ was significantly more frequent in neurons, diffuse deposits and core plaques in AD compared to OC cases. Scale bar (a) = 50 μm; (b-i) = 25 μm