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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease

Fig. 1

Regions of APP recognized by the antibodies used in this study. Top of the figure: Illustration of APP. Aβ region is labelled in yellow and β and γ-secretase cleavage sites are indicated in red. Bottom of the figure: Illustration of the Aβ and APP regions recognized by 22C8, 337.48, 82E1, 4G8 clones. The positions of IsoD- and pE3-Aβ modifications recognized, respectively by clones 22C8 and 337.48, are indicated with triangles

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