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Table 1 All examined cases of iCJD from countries of treatment with clinical, molecular and histopathological features

From: Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study

Case number Iatrogenic exposure Country Sex Age at death (years) Disease duration (months) Mean incubation perioda (years) Codon 129 genotype PrPSc type Histopath. phenotype Two or more histological sections
1 b,c DML United States M 26 5 19 na na MM(MV)1 yes
2d,e DMT   F 39 4 6 MM 1 MM(MV)1 yes
3 GH   M 33 6 23 VV na VV2 yes
4 GH   M 39 17 24 MV na MV2K yes
5 GH   M 39 7 27 MM 2 Atypical yes
6e GH   F 41 2 26 MM 1 MM(MV)1 yes
7 GH   M 43 26 23 MV i+2 MV2K yes
8 GH   M 44 18 32.5 MV i+2 MV2K yes
9 e GH   M 51 14 38 MM i MMi yes
10 e GH   M 54 2 41.5 MM 1 MM(MV)1 yes
11 GH   M 23 19 10 na na MV2K or MMi no
12 GH   M 34 18 23 na na MV2K or MMi no
13 GH   M 37 3 21 na na MM(MV)1 no
14 GH   M 42 5 >28f MM na Undeterminedg no
15h GH   M 52 4 43 na na MM(MV)1 no
mean±SDi     41±8.5 11±8 28±9.5j     
16 DML Australia M 32 3.5 16.5 MV na MM(MV)1 yes
17 k DML   M 62 2 5 na na MM(MV)1 yes
mean±SD     47±21 3±1 11±8     
18 DML France M 25 8 8 MV na MM(MV)1 yes
19 DMUnk   M 29 6 25 MV 1 MM(MV)1 yes
20 DML   M 42 5 6 VV na VV2 yes
21 DML   F 50 14 11 MM na MMi yes
22 DML   F 62 4 4 VV na VV2 yes
23 DML   F 71 4 4 MV na MV2K yes
mean±SD     46.5±18 7±4 10±8     
24 DML Italy F 23 27 21 VV 2 VV2 yes
25 DML   F 26 6 12 MM na MM(MV)1 no
26 DML   M 42 3.5 18 MM 1+2 MM1+2 yes
27 DML   M 75 3 18 VV 2 VV2 yes
mean±SD     41.5±24 10±11.5 17±4     
  1. aThe mean incubation period was measured from the mid-point of GH therapy or date of receipt of the dura graft to the clinical onset of the disease; b[3]; cNumbers in bold indicate iCJD cases with Aβ-positive pathology; d[32]; e [10]; fUnknown starting date for GH treatment (incubation period thought to be greater than 28 years); gAssociated with severe spongiosis and gliosis; hBiopsy; iMean±SD of the US iCJD cases does not include DML (case 1) and DMT (case 2); jIt does not include case 14; k[58]; Histopath. histopathological, DMUnk dura mater of an unknown (Unk) brand, na not available SD standard deviation