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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study

Fig. 3

Aβ and tau pathology of iCJD, sCJD and AD. a and b typical Aβ CP (arrows) from the frontal cortex of iCJD (a) and AD (b); inset a: Aβ CP at higher magnification immunoprobed for Aβ (top) or stained with Thioflavin S (bottom); inset b: Thioflavin S-positive Aβ CP. c diffuse plaques from the frontal cortex of a case of sCJD; inset: Thioflavin S-negative staining of plaques (dashed rectangle). d co-localization of Aβ (cyan dye) and PrP (brown dye) immunoreactivity in the same plaque from cerebral (I and III) and cerebellar (II) cortices of iCJD. I: plaque exhibiting a PrP-positive core surrounded by an Aβ immunoreactive crown; II-III: plaques showing either the immunostaining opposite to that of I, with Aβ-positive core and a PrP immunoreactive crown (II), or random distribution of PrP- and Aβ-reactive aggregates (III). e-g Aβ deposits (e) and Thioflavin S-positive staining (f and g) of vessels in frontal cortex (e), hippocampus (f) and cerebellum (g) in iCJD; f: DG, Dentate gyrus; g: asterisk, Aβ CAA in the subarachnoid space between two cerebellar folia. h Aβ CP predominantly affecting the granular layer (Grl. L) and Purkinje layer of the cerebellum in iCJD (case 9, Table 1); arrow indicates Aβ CP; large and small insets: enlargements of Aβ CP identified by the dashed rectangle in the main figure and a Thioflavin S-positive Aβ CP, respectively. i-j hippocampus free of tau pathology in iCJD (i) but severely affected in AD (j). k Tau-positive DN associated with an Aβ CP in frontal cortex of iCJD (case 8, Table 1) (dashed square); top inset: enlargement of tau reactive DN identified in dashed square; bottom inset: DN associated with a PrP kuru plaque in iCJD (occipital cortex, case 9, Table 1). l globose NFT (arrow) and neuropil threads (arrowhead) in the nucleus basalis of Meynert of iCJD (case 6, Table 1); inset: flame-shaped NFT in the temporal neocortex of the same iCJD case. Abs: 3F4 (d), 4G8 (a-e, h) and AT8 (i-l) to PrP, Aβ and phosphorylated tau, respectively; Thioflavin S to Aβ (a-c, f-h)

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