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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Brainstem tau pathology in Alzheimer’s disease is characterized by increase of three repeat tau and independent of amyloid β

Fig. 2

Topographical distribution is similar between NTs and NFTs, and between 4R and 3R tau. Representative immunolabel mapping of the tau deposition in separate isoform profiles (4R tau-positive/green, 3R tau-positive/red, 4R/3R tau both-positive/yellow), overlays, and amyloid β (Aβ, black). The number indicates the sum of immunolabels on each section. From top to bottom: the midbrain of case 5, 10, and 23, and the pons of case 3, 10, 23, with cortical NFT stages I/II, III/IV, V/VI, and the amount of local Aβ deposition of 0, +/++, +++, respectively. Bar = 2 mm. The dot sizes are irrelevant to the scale. Topographical distribution did not differ considerably between NFTs and NTs, and between tau isoform profiles. However, tau and Aβ deposits were different in their distribution, i.e.; at the periaqueductal gray (PAG, ventral-half vs. dorsal-half dominance in case 10), linear raphe nucleus (LRN), and dorsal raphe nucleus (DRN) (abundant tau deposition vs. few Aβ in cases 10 and 23)

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