TY - JOUR AU - Uematsu, Miho AU - Nakamura, Ayako AU - Ebashi, Momoko AU - Hirokawa, Katsuiku AU - Takahashi, Ryosuke AU - Uchihara, Toshiki PY - 2018 DA - 2018/01/03 TI - Brainstem tau pathology in Alzheimer’s disease is characterized by increase of three repeat tau and independent of amyloid β JO - Acta Neuropathologica Communications SP - 1 VL - 6 IS - 1 AB - Alzheimer-type neuropil threads (NTs) and neurofibrillary tangles (NFTs) are comprised of either 4 repeat (4R)-tau, 3 repeat (3R)-tau, or a mixture of both. In the hippocampus, the number of NFTs, and the proportion of 3R tau progressively increases. If this preferential accumulation of 3R tau also occurs in the brainstem, it may be fundamentally related to progression of Alzheimer pathology. SN - 2051-5960 UR - https://doi.org/10.1186/s40478-017-0501-1 DO - 10.1186/s40478-017-0501-1 ID - Uematsu2018 ER -