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Table 3 Relative risk of cerebrovascular outcome for participants with pairwise comparisons among the cohorts. Each outcome was dichotomized to indicate the presence versus absence of the finding. Relative risk was calculated and reported with the 95% confidence based on the score test for binomial outcomes

From: Cerebrovascular pathology in Down syndrome and Alzheimer disease

DS vs AD    Relative Riska
Cerebrovascular outcome AD (n = 80) DS (n = 32) Estimate (95% CI)
Atherosclerosis 43 (55.84%) 7 (22.58%) 0.40 (0.20, 0.74)
Arteriolosclerosis 36 (45.57%) 0 (0.00%) 0.00 (0.00, 0.24)
CAA 57 (72.15%) 27 (87.10%) 1.21 (0.96, 1.46)
DS vs Ctrl    Relative Risk
  Ctrl (n = 37) DS (n = 32) Estimate (95% CI)
Atherosclerosis 28 (75.68%) 7 (22.58%) 0.30 (0.15, 0.55)
Arteriolosclerosis 16 (43.24%) 0 (0.00%) 0.00 (0.00, 0.26)
CAA 7 (18.92%) 27 (87.10%) 4.60 (2.49, 9.29)
AD vs Ctrl    Relative Risk
  Ctrl (n = 37) AD (n = 80) Estimate (95% CI)
Atherosclerosis 28 (75.68%) 43 (55.84%) 0.74 (0.56, 0.99)
Arteriolosclerosis 16 (43.24%) 36 (45.57%) 1.05 (0.70, 1.68)
CAA 7 (18.92%) 57 (72.15%) 3.81 (2.07, 7.70)
  1. aCerebrovascular outcomes were dichotomized for the presence vs the absence of positive finding. Relative risk compares DS to AD, DS to Control and AD to Control. The confidence intervals were calculated using the score test for the binomial distribution