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Table 4 Survival times for each group of bank voles challenged with p-CJDMM1 and np-CJDMM1 inocula

From: Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature

sCJD case Bv109M Bv109I
  1st passage (A) 2nd passage (B) 1st passage (C) 2nd passage (D)
case #1 137 ± 7 146 ± 10 194 ± 15 212 ± 23
case a 188 ± 22 [18] 129 ± 8 [18] 288 ± 29 193 ± 21
case b 158 ± 13 [18] 143 ± 12 [18] NP NP
case c 145 ± 6 121 ± 10 NP NP
case d 179 ± 10 [18] 128 ± 15 [18] 270 ± 21 190 ± 8
  1. Values are expressed as mean ± standard deviation (days post inoculation). NP: not performed. Case #1: p-CJDMM1; cases a, c: np-CJDMM1; case b: np-gCJD E200K-MM1; case d: np-CJDMV1. All statistical analyses were performed with ANOVA on ranks followed by Dunn’s or Holm-Sidak tests for all pairwise multiple comparisons. For column (A), statistically significant differences were: inocula #1 and c versus inocula a and d, inocula b versus inocula #1, a and d (P < 0.05); for column (B), inocula #1 and b versus inocula a, c, d (P < 0.05); for column (C), inocula #1 versus inocula a and d (P < 0.05); for column (D), no significant differences (ANOVA on ranks)