sCJD case | Bv109M | Bv109I |
|---|
| Â | 1st passage (A) | 2nd passage (B) | 1st passage (C) | 2nd passage (D) |
|---|
case #1 | 137 ± 7 | 146 ± 10 | 194 ± 15 | 212 ± 23 |
case a | 188 ± 22 [18] | 129 ± 8 [18] | 288 ± 29 | 193 ± 21 |
case b | 158 ± 13 [18] | 143 ± 12 [18] | NP | NP |
case c | 145 ± 6 | 121 ± 10 | NP | NP |
case d | 179 ± 10 [18] | 128 ± 15 [18] | 270 ± 21 | 190 ± 8 |
- Values are expressed as mean ± standard deviation (days post inoculation). NP: not performed. Case #1: p-CJDMM1; cases a, c: np-CJDMM1; case b: np-gCJD E200K-MM1; case d: np-CJDMV1. All statistical analyses were performed with ANOVA on ranks followed by Dunn’s or Holm-Sidak tests for all pairwise multiple comparisons. For column (A), statistically significant differences were: inocula #1 and c versus inocula a and d, inocula b versus inocula #1, a and d (P < 0.05); for column (B), inocula #1 and b versus inocula a, c, d (P < 0.05); for column (C), inocula #1 versus inocula a and d (P < 0.05); for column (D), no significant differences (ANOVA on ranks)
