Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature

Table 3 Assessment of white matter lesions in 4 representative areas

Lesion	AREA	Case #1	Case #2	Case #3	Case #4	Case #5
Demyelination	Frontal cortex	++	++	+++	++	0
	Temporal cortex	++	++	+++	++	+
	Occipital cortex	+++	++	+++	++	0
	Cerebellum	++	++	++	+	+
Axonal damage	Frontal cortex	+	+	+++	++	0
	Temporal cortex	++	++	+++	+	0
	Occipital cortex	+	+	+++	+	0
	Cerebellum	+	+	+++	++	0
Astrocytosis	Frontal cortex	++	++	+++	++	0
	Temporal cortex	++	++	++	++	+
	Occipital cortex	++	++	++	++	+
	Cerebellum	+	+	+	+	+
Microgliosis	Frontal cortex	++	+++	+++	+++	+
	Temporal cortex	++	+++	+++	+++	+
	Occipital cortex	++	+++	+++	+++	+
	Cerebellum	+	++	++	+	+

Each lesion was scored semiquantitatively using a 0–3 scale (0, absence of significant abnormalities: + mild, ++ moderate, and +++ severe changes). The list of staining used for the assessment are listed in the materials and methods

ISSN: 2051-5960