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Table 3 Assessment of white matter lesions in 4 representative areas

From: Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature

Lesion AREA Case #1 Case #2 Case #3 Case #4 Case #5
Demyelination Frontal cortex ++ ++ +++ ++ 0
Temporal cortex ++ ++ +++ ++ +
Occipital cortex +++ ++ +++ ++ 0
Cerebellum ++ ++ ++ + +
Axonal damage Frontal cortex + + +++ ++ 0
Temporal cortex ++ ++ +++ + 0
Occipital cortex + + +++ + 0
Cerebellum + + +++ ++ 0
Astrocytosis Frontal cortex ++ ++ +++ ++ 0
Temporal cortex ++ ++ ++ ++ +
Occipital cortex ++ ++ ++ ++ +
Cerebellum + + + + +
Microgliosis Frontal cortex ++ +++ +++ +++ +
Temporal cortex ++ +++ +++ +++ +
Occipital cortex ++ +++ +++ +++ +
Cerebellum + ++ ++ + +
  1. Each lesion was scored semiquantitatively using a 0–3 scale (0, absence of significant abnormalities: + mild, ++ moderate, and +++ severe changes). The list of staining used for the assessment are listed in the materials and methods