Fig. 4

Bank voles lesion profiles. Lesion profiles of the p-sCJDMM1 case #1 (red line) and 4 control np-sCJDMM(V)1 (black lines) transmissions in Bv109M and Bv109I lines after first (a, b) and second (c, d) passage. Control case are denoted by: case a, white triangle down; case b, black square; case c, white diamond; case d, black triangle up. Case a, b and d were previously reported [18]. Brain-scoring positions include medulla (1), cerebellum (2), superior colliculus (3), hypothalamus (4), thalamus (5), hippocampus (6), septum (7), retrosplenial and adjacent motor cortex (8), and cingulate and adjacent motor cortex (9). Strong similarities characterize the lesion profiles of all these transmissions