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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature

Fig. 2

Histopathological findings in p-CJDMM1. a Severe neuronal loss and gliosis and status spongiosus in the temporal cortex (case #1, H&E stain, ×100); b typical spongiform change in the CA1 sector of the hippocampus (case #1, H&E stain, ×200); c synaptic (grey matter) and plaque-like (white matter) PrP deposition in the temporal cortex (case #1, PrP immunohistochemistry, ×100); d PrP-positive amyloid plaques in the cerebellar white matter (case #2, PrP immunohistochemistry, ×400); e, f amyloid plaques in the temporal cortical white matter occasionally co-localizing (f) with APP positive axons (case #1, PAS stain + APP immunohistochemistry, e = ×800, f = ×1000)

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