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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers

Fig. 5

Comparing urine and CSF exosomal LRRK2-expression and phosphorylation profiles. a Correlation of total LRRK2 and TSG101 in urine (N=132), and (b) total LRRK2 and flotillin-1 in CSF (N=81). c Correlation of total exosomal LRRK2 protein in CSF and urine, and (d) pS1292-LRRK2 in CSF and urine. Without adjusting for housekeeping exosome protein concentrations, correlation for (e) total LRRK2 protein and (f) pS1292-LRRK2 protein in CSF and urine. Samples were matched to the same clinic visit. (N=56, green: LRRK2- PD-, black: LRRK2+ PD-, red: LRRK2+ PD+, blue: LRRK2- PD+). Spearman's rank correlation coefficients are shown with corresponding p values

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Acta Neuropathologica Communications

ISSN: 2051-5960

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