Epigenetic control of epilepsy target genes contributes to a cellular memory of epileptogenesis in cultured rat hippocampal neurons

Table 4 Epilepsy-associated genes previously reported to be epigenetically regulated

Epilepsy-ass. Gene	Previously described epigenetic modification	Organism and Experimental condition	Reference
Bdnf	DNA methylation	Rat HC primary neuronal culture (high K+)	[11]
	H3/H4 acteylation	Rat ECS model	[18]
	DNA methylation	Rat SE model (KA)	[13]
	Chromatin remodeling	Rat SE model (KA)	[48]
c-Fos	H3 phosphorylation	Mouse SE model (KA)	[49]
	H3/H4 acetylation	Rat ECS model	[18]
	H4 acetylation	Mouse SE model (KA)	[17]
Cpa6	DNA methylation	Human TLE-HS	[8]
Creb	H3/H4 acetylation	Rat ECS model	[18]
Gria2	H4 acetylation	Rat SE model (PILO)	[15]
Grin2a	H4K12 acetylation	Animal models of AD	[30]
Grin2a	DNA methylation	Human Depression	[31]
Grin2b	DNA methylation	Rat SE model (KA)	[13]
Reelin	DNA methylation	Human TLE-HS	[10]
Genome-wide alterations	DNA methylation	Rat SE model (PILO)	[50]
		Rat SE model (KA)	[51]
		Rat SE model (KA)	[14]
		Mouse SE model (KA)	[51]
		Human TLE-HS	[12]
		Rat SE model (SSSE), Rat TBI model, and Rat SE model (PILO)	[9]

ISSN: 2051-5960