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Table 2 Comparison of scrapie disease in WT rats with Tg animals overexpressing PrP in the CNS

From: A novel vector for transgenesis in the rat CNS

Line Expression Level Inoculum Mean incubation period ± SEM (d) Mean age at disease onset (d) n/n0
WT rat rat RML 175 ± 3 224 ± 3 7/7
Tg2919 4.4× None N/A >460 0/4
   rat RML 149 ± 2 210 ± 2 8/8
Tg2922 9.7× None N/A >360 0/12
   rat RML 112 ± 0 198 ± 0 7/7