Table 2 Comparison of scrapie disease in WT rats with Tg animals overexpressing PrP in the CNS
Line | Expression Level | Inoculum | Mean incubation period ± SEM (d) | Mean age at disease onset (d) | n/n0 |
|---|---|---|---|---|---|
WT rat | 1× | rat RML | 175 ± 3 | 224 ± 3 | 7/7 |
Tg2919 | 4.4× | None | N/A | >460 | 0/4 |
rat RML | 149 ± 2 | 210 ± 2 | 8/8 | ||
Tg2922 | 9.7× | None | N/A | >360 | 0/12 |
rat RML | 112 ± 0 | 198 ± 0 | 7/7 |