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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: A novel vector for transgenesis in the rat CNS

Fig. 8

Neuropathology of WT and Tg rats. Neuropathological characterization of WT (ad), Tg2919 (eh), and Tg2922 (il) uninoculated rats or animals inoculated with NBH or rat RML. Vacuoles were mainly present at moderate to frequent densities in rats inoculated with rat RML; representative images of the striatum (a, b, e, and f) and brainstem (i and j). PrP deposition was absent in WT rats inoculated with NBH (c) but was moderate to frequent in rats inoculated with rat RML (d, h, and l). Only diffuse immunoreactivity was found in uninoculated Tg2919 animals (g). Some focal PrP deposits were seen in Tg2922 rats (k). Images from the striatum (c, d, g, and h) and brainstem (k and l). All scale bars = 100 μm. Scale bar in (a) corresponds to images in (bf). Scale bar (g) corresponds to (h), and scale bar (i) to (jl)

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