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Table 1 Changes in cytokine/chemokine levels in plasma and in different brain regions as a consequence of blast exposure, measured at 6 weeks post-blast exposure

From: Lack of chronic neuroinflammation in the absence of focal hemorrhage in a rat model of low-energy blast-induced TBI

  L-Hipp R-Hipp L-Amy R-Amy L-AC R-AC L-PC R-PC Plasma
EGF ND ND ND ND ND ND ND ND ND
Eotaxin ND ND ND ND ND ND ND ND ND
Fractalkine NC NC NC NC NC 1.4↓p = 0.08 1.5↓p = 0.01 NC 1.6↓p = 0.004
G-CSF NC NC NC NC NC NC NC NC ND
GM-CSF NC NC NC NC NC NC NC NC ND
GRO/KC NC NC NC NC NC NC NC 1.4↑p = 0.008 ND
IFNγ NC NC NC NC NC NC NC NC ND
IL-10 NC NC NC NC NC NC NC NC ND
IL-12p70 NC NC NC NC NC NC NC NC NC
IL-13 2.2↓p = 0.07 NC NC ND NC ND ND ND NC
IL-18 1.9↓p = 0.03 NC NC NC NC 1.4↓p = 0.09 1.7↓p = 0.02 NC ND
IL-1α 1.5↓p = 0.02 NC NC NC NC 2.5↓p = 0.09 NC NC NC
IL-1β NC 2.5↓p = 0.07 NC NC NC NC NC NC 1.8↓p = 0.048
IL-2 NC NC NC NC NC NC NC 1.7↑p = 0.02 NC
IL-4 NC NC NC NC NC NC NC NC NC
IL-5 1.5↓p = 0.02 NC NC NC ND ND ND ND NC
IL-6 1.8↓p = 0.02 NC NC NC NC NC ND ND NC
IL-17A ND ND ND ND ND ND ND ND ND
IP-10 NC NC NC NC NC NC NC NC NC
Leptin NC 1.8↓p = 0.01 ND NC NC NC NC 1.9↑p = 0.02 1.5↓p = 0.061
LIX NC NC 5↓p = 0.001 10↓p = 0.08 ND 11.2↓p = 0.02 ND ND 1.8↓p = 0.006
MCP-1 1.2↓p = 0.09 NC NC NC NC ND NC NC NC
MIP-1α NC NC NC ND ND ND ND ND 1.6↓p = 0.011
MIP-2 NC NC NC NC NC NC NC NC ND
RANTES ND ND NC ND ND NC ND ND NC
TNFα 1.4↓p = 0.08 NC NC NC NC NC NC 1.5↑p = 0.005 ND
VEGF NC NC NC NC NC ND ND ND 1.4↓p = 0.007
  1. Up or down arrows indicate increased or decreased relative levels in blast-exposed versus control animals. The respective p value (unpaired t-tests) is also indicated. NC, no change, ND = not detected. L or R indicate left or right subregion, respectively. Hipp = Hippocampus, Amy = Amygdala, AC = Anterior cortex, PC = Posterior cortex