Fig. 5

CLU expression reduces TDP-43 toxicity in Drosophila motor neurons. Time-dependent differences between Drosophila expressing TDP-43 +/− CLU in (a) motor function, measured by climbing assay, and (b) survival, compared to non-transgenic (Non-TG) Drosophila. In (a) and (b), values shown are means +/− SEM, and in each case the results shown are representative of three independent experiments. Parent lines used in crosses indicated in key. Differences in climbing index between genotypes were analysed by ANOVA (n = 30). Lifespans were analysed by Kaplan Meier statistics (n = 90). See also Additional file 1: Figure S7