Fig. 5From: Glial cells are functionally impaired in juvenile neuronal ceroid lipofuscinosis and detrimental to neuronsAltered protein secretion profiles of Cln3 −/− microglia. Secreted protein levels were quantified from supernatants collected from WT and Cln3 −/− microglial cultures grown under basal conditions, or after stimulation with LPS. Following quantitative analysis of 59 soluble factors, 5 were found to be secreted at significantly lower levels by Cln3-deficient (Cln3 −/−) microglia over time in culture compared to wild type (WT) microglial cultures. These included the chemokines MIP-1-γ, MIP-2 and RANTES, the glycoprotein vWF, and the matrix metalloproteinase MMP-9Back to article page