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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2 N141I neurons

Fig. 5

BFCNs carrying various PSEN mutations are not consistently more susceptible to Aβ42 oligomer toxicity. a Sample images of BFCNs from the indicated genotypes treated with propidium iodide to visualize cell death in response to 72-h exposure to Aβ42 oligomers (5 μM). b % LDH Release recorded from media collected after 72-h exposure. n = 3, 3 independent experiments with technical triplicates. *, p < .05; **, p < .01 as detected by 2-Way ANOVA Bonferroni post hoc tests

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Acta Neuropathologica Communications

ISSN: 2051-5960

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