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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Alzheimer’s disease pathological lesions activate the spleen tyrosine kinase

Fig. 7

pSyk is increased age-dependently in cortical neurons of Tg Tau P301S mice compared to wild-type littermates. Representative confocal image depicting Tg Tau P301S and wild-type mice (n = 16) stained with antibodies against pTau (S202, purple), pSyk (Y525/526, green) and Iba-1 (red). Nuclei were stained with DAPI. a-e Tau-overexpressing Tg Tau P301S mice exhibited a prominent tau phosphorylation (S202) that increased with age and partially colocalized with Syk activation in cortical neurons. f Wild-type mice did not exhibit any tau phosphorylation nor Syk activation in their cortices. The scale bar represents 10 μm

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