Fig. 6
From: Alzheimer’s disease pathological lesions activate the spleen tyrosine kinase
pSyk is increased age-dependently in hippocampal neurons of Tg Tau P301S mice compared to wild-type littermates. Representative confocal image depicting Tg Tau P301S and wild-type mice (n = 16) stained with antibodies against pTau (S202, purple), pSyk (Y525/526, green) and Iba-1 (red). Nuclei were stained with DAPI. a-e Tau-overexpressing Tg Tau P301S mice exhibited a prominent tau phosphorylation (S202) that increased with age and colocalized with Syk activation in hippocampal neurons. f Wild-type mice did not exhibit any tau phosphorylation nor Syk activation in their hippocampi. The scale bar represents 10 μm