Fig. 5
From: Alzheimer’s disease pathological lesions activate the spleen tyrosine kinase
pSyk is increased in cortical neurons of Tg Tau P301S mice compared to wild-type littermates. Representative confocal image depicting 56 week-old male Tg Tau P301S and wild-type mice stained with antibodies against pTau (S202, purple), pSyk (Y525/526, green). a Wild-type mice did not exhibit any tau phosphorylation nor Syk activation in their cortices. b Tau-overexpressing Tg Tau P301S mice exhibited a prominent tau phosphorylation at S202 that colocalized with Syk activation in cortical neurons. The scale bars represent 100 μm