Fig. 4From: Alzheimer’s disease pathological lesions activate the spleen tyrosine kinasepSyk is increased in hippocampal neurons of Tg Tau P301S mice compared to wild-type littermates. Representative confocal image depicting 56 week-old male Tg Tau P301S and wild-type mice stained with antibodies against pTau (S202, purple) and pSyk (Y525/526, green). a Wild-type mice did not exhibit any tau phosphorylation nor Syk activation in their hippocampi. b Tau-overexpressing Tg Tau P301S mice exhibited a prominent tau phosphorylation at S202 that colocalized with Syk activation in hippocampal neurons. The scale bars represent 200 μmBack to article page