Fig. 16
From: Alzheimer’s disease pathological lesions activate the spleen tyrosine kinase
pSyk is increased in cortical neurons immunopositive for MC1 pathogenic Tau conformers in AD compared to brain sections from a non-demented control. Representative confocal images of the dorsolateral frontal cortex sections of human AD (b) were stained with antibodies against conformationally altered tau species (MC1) (purple), pSyk (525/526) (green), Iba-1 (red) and GFAP (blue) and compared to non-demented control brain sections (a). a The non-demented control (102-year-old, male) does not exhibit any cells immunopositive for MC1 nor increased in Syk activation in the dorsolateral frontal cortex. b The AD brain (67-year-old, male) exhibits neurons strongly immunopositive for MC1 that colocalize with Syk activation (Y525/526) in cortical neurons. The scale bars represent 10 μm