Fig. 5
From: Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration
Proposed stages of intracortical region-specific decline in FTLD-TDP. This illustration defines three stages of regional decline in the cerebral cortex of FTLD-TDP that proceed from the aggregation of pTDP-43 inclusions to degeneration of tissue. NC is characterized by healthy neurons and a lack of pathology. In Stage 1, pathology begins to aggregate and neuronal health is maintained. Likewise, in Stage 2, neuronal health is maintained but an increase in pathological aggregates is observed. Lastly, Stage 3 is typified by a clearance of pathology, tissue degeneration, and depressed neuronal health. In this model, the presence of NeuN, SFPQ, and HuC/HuD proteins distinguishes healthy neurons